Journal article
Mineralization and bone resorption are regulated by the androgen receptor in male mice
C Chiang, M Chiu, AJ Moore, PH Anderson, A Ghasem-Zadeh, JF McManus, M Cathy, E Seeman, TL Clemens, HA Morris, JD Zajac, RA Davey
Journal of Bone and Mineral Research | Published : 2009
DOI: 10.1359/jbmr.081217
Abstract
Androgens play a key role in skeletal growth and bone maintenance; however, their mechanism of action remains unclear. To address this, we selectively deleted the and rogen receptor (AR) in terminally differentiated, mineralizing osteoblasts using the Cre/loxP system in mice (osteocalcin-Cre AR knockouts [mOBL-ARKOs]). Male mOBL-ARKOs had decreased femoral trabecular bone volume compared with littermate controls because of a reduction in trabecular number at 6, 12, and 24 wk of age, indicative of increased bone resorption. The effects of AR inactivation in mineralizing osteoblasts was most marked in the young mutant mice at 6 wk of age when rates of bone turnover are high, with a 35% reducti..
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Awarded by National Health and Medical Research Council, Australia
Funding Acknowledgements
The authors thank Patricia Russell and Elizabeth Doust of the Department of Medicine, Austin Health, University of Melbourne, and Rebecca Sawyer of the Hanson Institute for excellent technical assistance. This study was funded by the National Health and Medical Research Council, Australia (Project Grant 350346). CC was supported by a Leslie Eric Paddle Scholarship, University of Melbourne. PHA was supported an Early Career Research Fellowship provided by the Faculty of Health Sciences, University of Adelaide.